Article
A genetic variant in the region of MMP-9 is associated with serum levels and progression of joint damage in rheumatoid arthritis.
Annals of the rheumatic diseases - 1 Jun 2014
de Rooy D P C, Zhernakova A, Tsonaka R, Willemze A, Kurreeman B A S, Trynka G, van Toorn L, Toes R E M, Huizinga T W J, Houwing-Duistermaat J J, Gregersen P K, van der Helm-van Mil A H M
Abstract excerpt
OBJECTIVES: The severity of joint destruction is highly variable between rheumatoid arthritis (RA) patients. The majority of its heritability is still unexplained. Several autoimmune diseases share genetic risk variants that may also influence disease progression. We aimed to identify genetic risk factors for the severity of joint damage in RA by studying genetic susceptibility loci of several autoimmune...
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