Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Do Genetic Susceptibility Variants Associate with Disease Severity in Early Active Rheumatoid Arthritis?

The Journal of rheumatology - 1 Jul 2015

Scott Ian C, Rijsdijk Frühling, Walker Jemma, Quist Jelmar, Spain Sarah L, Tan Rachael, Steer Sophia, Okada Yukinori, Raychaudhuri Soumya, Cope Andrew P, Lewis Cathryn M

Abstract excerpt

OBJECTIVE: Genetic variants affect both the development and severity of rheumatoid arthritis (RA). Recent studies have expanded the number of RA susceptibility variants. We tested the hypothesis that these associated with disease severity in a clinical trial cohort of patients with early, active RA. METHODS: We evaluated 524 patients with RA enrolled in the Combination Anti-Rheumatic Drugs in Early RA (CARDERA)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Antirheumatic Agents

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Arthritis, Rheumatoid

Share to Disease Progression

Share to Genetic Association Studies

Share to HLA-DRB1 Chains

Share to Models, Theoretical

Share to Severity of Illness Index

Source

Open in PubMed Open full text

Identifiers

PMID: 25979711
DOI: 10.3899/jrheum.141211
PMCID: PMC6714044

Genes

PTPN11
STAT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Do Genetic Susceptibility Variants Associate with Disease Severity in Early Active Rheumatoid Arthritis?PMID 25979711Read ↗

Association of HLA-DRB1 haplotypes with rheumatoid arthritis severity, mortality, and treatment response.Semantic proximity Read ↗

Genetic Factors for the Severity of ACPA-negative Rheumatoid Arthritis in 2 Cohorts of Early Disease: A Genome-wide Study.Semantic proximity Read ↗

Predicting the severity of joint damage in rheumatoid arthritis; the contribution of genetic factors.Semantic proximity Read ↗

Genetics of rheumatoid arthritis susceptibility, severity, and treatment response.Semantic proximity Read ↗

PADI4 and HLA-DRB1 are genetic risks for radiographic progression in RA patients, independent of ACPA status: results from the IORRA cohort study.Semantic proximity Read ↗

Genetic influences modulating the radiological severity of rheumatoid arthritis.Semantic proximity Read ↗

HLA-DRB1 Amino Acid Positions 11/13, 71, and 74 Are Associated With Inflammation Level, Disease Activity, and the Health Assessment Questionnaire Score in Patients With Inflammatory Polyarthritis.Semantic proximity Read ↗

Genetic Polymorphisms Associated with Rheumatoid Arthritis Development and Antirheumatic Therapy Response.Semantic proximity Read ↗

Associations of toll-like receptor (TLR)-4 single nucleotide polymorphisms and rheumatoid arthritis disease progression: an observational cohort study.Semantic proximity Read ↗

Genetic risk score predicting risk of rheumatoid arthritis phenotypes and age of symptom onset.Semantic proximity Read ↗

Large-scale meta-analysis across East Asian and European populations updated genetic architecture and variant-driven biology of rheumatoid arthritis, identifying 11 novel susceptibility loci.Semantic proximity Read ↗

Association of Polygenic Risk Scores With Radiographic Progression in Patients With Rheumatoid Arthritis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.