The prognostic effect of high diagnostic WT1 gene expression in pediatric AML depends on WT1 SNP rs16754 status: report from the Children's Oncology Group.

doi:10.1002/pbc.24700

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Article

The prognostic effect of high diagnostic WT1 gene expression in pediatric AML depends on WT1 SNP rs16754 status: report from the Children's Oncology Group.

Pediatric blood & cancer - 1 Jan 2014

Ho Phoenix A, Alonzo Todd A, Gerbing Robert B, Kuhn Julia, Pollard Jessica A, Hirsch Betsy, Raimondi Susana C, Gamis Alan S, Meshinchi Soheil

Abstract excerpt

BACKGROUND: WT1 is aberrantly over-expressed in most cases of AML. We recently demonstrated that WT1 SNP rs16754 correlates with favorable outcome and high diagnostic WT1 expression in childhood AML. We examined the clinical correlates of diagnostic WT1 expression within a contemporary COG trial and determined whether its prognostic impact differs between SNP+ and SNP- patients. PROCEDURE: WT1 mRNA expression was...

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PMID: 23956224
DOI: 10.1002/pbc.24700

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EFS
FLT3

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