Article
Clinical outcome and gene- and microRNA-expression profiling according to the Wilms tumor 1 (WT1) single nucleotide polymorphism rs16754 in adult de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study.
Haematologica - 1 Oct 2011
Becker Heiko, Maharry Kati, Radmacher Michael D, Mrózek Krzysztof, Metzeler Klaus H, Whitman Susan P, Schwind Sebastian, Kohlschmidt Jessica, Wu Yue-Zhong, Powell Bayard L, Carter Thomas H, Kolitz Jonathan E, Wetzler Meir, Carroll Andrew J, Baer Maria R, Moore Joseph O, Caligiuri Michael A, Larson Richard A, Marcucci Guido, Bloomfield Clara D
Abstract excerpt
BACKGROUND: The alleles of the Wilms tumor 1 (WT1) polymorphism rs16754 harbor adenine (A) or guanine (G). Recently, rs16754 has been reported to affect the outcome of patients with cytogenetically normal acute myeloid leukemia. To validate this finding, we investigated pretreatment features and outcome associated with rs16754 in a large cohort of patients with cytogenetically normal acute myeloid leukemia....
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