Single nucleotide polymorphism in the mutational hotspot of WT1 predicts a favorable outcome in patients with cytogenetically normal acute myeloid leukemia.

doi:10.1200/JCO.2009.23.0342

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Article

Single nucleotide polymorphism in the mutational hotspot of WT1 predicts a favorable outcome in patients with cytogenetically normal acute myeloid leukemia.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Feb 2010

Damm Frederik, Heuser Michael, Morgan Michael, Yun Haiyang, Grosshennig Anika, Göhring Gudrun, Schlegelberger Brigitte, Döhner Konstanze, Ottmann Oliver, Lübbert Michael, Heit Wolfgang, Kanz Lothar, Schlimok Günter, Raghavachar Aruna, Fiedler Walter, Kirchner Hartmut, Döhner Hartmut, Heil Gerhard, Ganser Arnold, Krauter Jürgen

Abstract excerpt

PURPOSE: We assessed the prognostic impact of a known single nucleotide polymorphism (SNP) located in the mutational hotspot of WT1 in patients with cytogenetically normal acute myeloid leukemia (CN-AML) in the context of other prognostic markers. PATIENTS AND METHODS: WT1 exons 7 and 9 from 249 CN-AML patients from multicenter treatment trials AML-SHG Hannover 0199 (Clinical Trials Identifier NCT00209833) and...

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Identifiers

PMID: 20038731
DOI: 10.1200/JCO.2009.23.0342

Genes

FLT3
NPM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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