Analysis of mutational status, SNP rs16754, and expression levels of Wilms tumor 1 (WT1) gene in acute promyelocytic leukemia.

doi:10.1007/s00277-012-1546-7

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Article

Analysis of mutational status, SNP rs16754, and expression levels of Wilms tumor 1 (WT1) gene in acute promyelocytic leukemia.

Annals of hematology - 1 Dec 2012

Gaur Girish Chander, Ramadan Safaa M, Cicconi Laura, Noguera Nélida I, Luna Irene, Such Esperanza, Lavorgna Serena, Di Giandomenico Jonny, Sanz Miguel A, Lo-Coco Francesco

Abstract excerpt

Overexpression, polymorphisms, and mutations of the WT1 gene have been reported in several human tumors including acute myeloid leukemia (AML) and variably correlated with prognosis. Acute promyelocytic leukemia (APL) represents the AML subset disclosing higher WT1 expression levels; however, no WT1 studies specifically focused on APL have been conducted. We screened for the presence of mutations, SNP rs16754,...

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PMID: 22895555
DOI: 10.1007/s00277-012-1546-7

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