WT1 synonymous single nucleotide polymorphism rs16754 correlates with higher mRNA expression and predicts significantly improved outcome in favorable-risk pediatric acute myeloid leukemia: a report from the children's oncology group.

doi:10.1200/JCO.2010.31.9327

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Article

WT1 synonymous single nucleotide polymorphism rs16754 correlates with higher mRNA expression and predicts significantly improved outcome in favorable-risk pediatric acute myeloid leukemia: a report from the children's oncology group.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Feb 2011

Ho Phoenix A, Kuhn Julia, Gerbing Robert B, Pollard Jessica A, Zeng Rong, Miller Kristen L, Heerema Nyla A, Raimondi Susana C, Hirsch Betsy A, Franklin Janet L, Lange Beverly, Gamis Alan S, Alonzo Todd A, Meshinchi Soheil

Abstract excerpt

PURPOSE: To analyze the prevalence and clinical implications of Wilms' tumor 1 (WT1) single nucleotide polymorphism (SNP) rs16754 in the context of other prognostic markers in pediatric acute myeloid leukemia (AML). PATIENTS AND METHODS: Available diagnostic marrow specimens (n = 790) from 1,328 patients enrolled in three consecutive Children's Cancer Group/Children's Oncology Group trials were analyzed for the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21189390
DOI: 10.1200/JCO.2010.31.9327
PMCID: PMC3056655

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