Article
WT1 mutations and single nucleotide polymorphism rs16754 analysis of patients with pediatric acute myeloid leukemia in a Chinese population.
Leukemia & lymphoma - 1 Nov 2012
Chen Xi, Yang Yongchen, Huang Yi, Tan Junjie, Chen Yuanyuan, Yang Jing, Dou Hu, Zou Lin, Yu Jie, Bao Liming
Abstract excerpt
Acute myeloid leukemia (AML) is relatively rare in children. Somatic mutations including the single nucleotide polymorphism (SNP) rs16754 in Wilms tumor 1 gene (WT1) and their prognostic relevance in pediatric AML have not been studied in Chinese populations. We analyzed WT1 mutations and rs16754 genotypes in a cohort of 86 patients with de novo pediatric AML in a Chinese population. We detected WT1 mutations in...
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