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Article

Population-based analysis of Alzheimer's disease risk alleles implicates genetic interactions.

Biological psychiatry - 1 May 2014

Ebbert Mark T W, Ridge Perry G, Wilson Andrew R, Sharp Aaron R, Bailey Matthew, Norton Maria C, Tschanz JoAnn T, Munger Ronald G, Corcoran Christopher D, Kauwe John S K

Abstract excerpt

BACKGROUND: Reported odds ratios and population attributable fractions (PAF) for late-onset Alzheimer's disease (LOAD) risk loci (BIN1, ABCA7, CR1, MS4A4E, CD2AP, PICALM, MS4A6A, CD33, and CLU) come from clinically ascertained samples. Little is known about the combined PAF for these LOAD risk alleles and the utility of these combined markers for case-control prediction. Here we evaluate these loci in a large...

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Source

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Identifiers

PMID: 23954108
DOI: 10.1016/j.biopsych.2013.07.008
PMCID: PMC3867586

Genes

APOE
CLU
ABCA7
BIN1
PICALM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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