Article
Late-onset Alzheimer's risk variants in memory decline, incident mild cognitive impairment, and Alzheimer's disease.
Neurobiology of aging - 1 Jan 2015
Carrasquillo Minerva M, Crook Julia E, Pedraza Otto, Thomas Colleen S, Pankratz V Shane, Allen Mariet, Nguyen Thuy, Malphrus Kimberly G, Ma Li, Bisceglio Gina D, Roberts Rosebud O, Lucas John A, Smith Glenn E, Ivnik Robert J, Machulda Mary M, Graff-Radford Neill R, Petersen Ronald C, Younkin Steven G, Ertekin-Taner Nilüfer
Abstract excerpt
We tested association of nine late-onset Alzheimer's disease (LOAD) risk variants from genome-wide association studies (GWAS) with memory and progression to mild cognitive impairment (MCI) or LOAD (MCI/LOAD) in older Caucasians, cognitively normal at baseline and longitudinally evaluated at Mayo Clinic Rochester and Jacksonville (n>2000). Each variant was tested both individually and collectively using a weighted...
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