Article
Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE.
PLoS genetics - 1 Feb 2011
Wijsman Ellen M, Pankratz Nathan D, Choi Yoonha, Rothstein Joseph H, Faber Kelley M, Cheng Rong, Lee Joseph H, Bird Thomas D, Bennett David A, Diaz-Arrastia Ramon, Goate Alison M, Farlow Martin, Ghetti Bernardino, Sweet Robert A, Foroud Tatiana M, Mayeux Richard
Abstract excerpt
Late-onset Alzheimer's disease (LOAD) is the most common form of dementia in the elderly. The National Institute of Aging-Late Onset Alzheimer's Disease Family Study and the National Cell Repository for Alzheimer's Disease conducted a joint genome-wide association study (GWAS) of multiplex LOAD families (3,839 affected and unaffected individuals from 992 families plus additional unrelated neurologically evaluated...
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