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Article

Alzheimer's disease genes and cognition in the nondemented general population.

Biological psychiatry - 1 Mar 2013

Verhaaren Benjamin F J, Vernooij Meike W, Koudstaal Peter J, Uitterlinden André G, van Duijn Cornelia M, Hofman Albert, Breteler Monique M B, Ikram M Arfan

Abstract excerpt

BACKGROUND: Genome-wide association studies have established 11 genes for late-onset Alzheimer's disease (AD). We investigated whether these genes jointly affect cognition in a nondemented population and improve prediction of AD. METHODS: In 5171 nondemented people (age 45-99 years) from the population-based Rotterdam Study, we genotyped APOE-ε4 and single nucleotide polymorphisms from the genes CLU, PICALM,...

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Source

Identifiers

PMID: 22592056
DOI: 10.1016/j.biopsych.2012.04.009

Genes

APOE
ABCA7
BIN1
CLU
EPHA1
PICALM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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