Article
Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory.
Neurology - 8 May 2012
Barral S, Bird T, Goate A, Farlow M R, Diaz-Arrastia R, Bennett D A, Graff-Radford N, Boeve B F, Sweet R A, Stern Y, Wilson R S, Foroud T, Ott J, Mayeux R
Abstract excerpt
OBJECTIVE: Several genome-wide association studies (GWAS) have associated variants in late-onset Alzheimer disease (LOAD) susceptibility genes; however, these single nucleotide polymorphisms (SNPs) have very modest effects, suggesting that single SNP approaches may be inadequate to identify genetic risks. An alternative approach is the use of multilocus genotype patterns (MLGPs) that combine SNPs at different...
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