Article
GSK3B and MAPT polymorphisms are associated with grey matter and intracranial volume in healthy individuals.
PloS one - 1 Jan 2013
Dobson-Stone Carol, Polly Patsie, Korgaonkar Mayuresh S, Williams Leanne M, Gordon Evian, Schofield Peter R, Mather Karen, Armstrong Nicola J, Wen Wei, Sachdev Perminder S, Kwok John B J
Abstract excerpt
The microtubule-associated protein tau gene (MAPT) codes for a protein that plays an integral role in stabilisation of microtubules and axonal transport in neurons. As well as its role in susceptibility to neurodegeneration, previous studies have found an association between the MAPT haplotype and intracranial volume and regional grey matter volumes in healthy adults. The glycogen synthase kinase-3β gene (GSK3B)...
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