Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association analysis of GSK3B and MAPT polymorphisms with Alzheimer's disease in Han Chinese.

Brain research - 19 May 2011

Zhang Na, Yu Jin-Tai, Yang Ying, Yang Jing, Zhang Wei, Tan Lan

Abstract excerpt

Aberrant phosphorylated tau is the major component of the neurofibrillary tangles in Alzheimer's disease (AD) brains. Glycogen synthase kinase-3beta (GSK-3B) phosphorylates tau protein, and increased GSK-3B expression has been associated with neurofibrillary tangles. To determine whether polymorphisms in the GSK3B gene and microtubule associated protein tau (MAPT) gene underpin susceptibility to late-onset...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Asian People
Share to Chi-Square Distribution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycogen Synthase Kinase 3

Share to Glycogen Synthase Kinase 3 beta

Share to Logistic Models

Share to Promoter Regions, Genetic

Share to tau Proteins

Source

Identifiers

PMID: 21443865
DOI: 10.1016/j.brainres.2011.03.052

Genes

MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association analysis of GSK3B and MAPT polymorphisms with Alzheimer's disease in Han Chinese.PMID 21443865Read ↗

Glycogen synthase kinase-3beta and tau genes interact in Alzheimer's disease.Semantic proximity Read ↗

MAPT rs242562 and GSK3B rs334558 are associated with Parkinson's Disease in central China.Semantic proximity Read ↗

Tau-tubulin kinase-1 gene variants are associated with Alzheimer's disease in Han Chinese.Semantic proximity Read ↗

Genetic variants of GSK3B are associated with biomarkers for Alzheimer's disease and cognitive function.Semantic proximity Read ↗

Association of MAPT haplotypes with Alzheimer’s disease risk and MAPT brain gene expression levelsSemantic proximity Read ↗

Association between polymorphisms in transforming growth factor-β1 and sporadic Alzheimer's disease in a Chinese population.Semantic proximity Read ↗

GSK3B and MAPT polymorphisms are associated with grey matter and intracranial volume in healthy individuals.Semantic proximity Read ↗

Association of GSK3B with Alzheimer disease and frontotemporal dementia.Semantic proximity Read ↗

Common variant in PTK2B is associated with late-onset Alzheimer's disease: A replication study and meta-analyses.Semantic proximity Read ↗

GSK3β polymorphisms, MAPT H1 haplotype and Parkinson's disease in a Greek cohort.Semantic proximity Read ↗

Common Polymorphisms in the GSK3β Gene May Contribute to the Pathogenesis of Alzheimer Disease: A Meta-Analysis.Semantic proximity Read ↗

GSK3β reduces risk of sporadic Parkinson's disease in ethnic Chinese.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.