Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide association study identifies MAPT locus influencing human plasma tau levels.

Neurology - 14 Feb 2017

Chen Jason, Yu Jin-Tai, Wojta Kevin, Wang Hui-Fu, Zetterberg Henrik, Blennow Kaj, Yokoyama Jennifer S, Weiner Michael W, Kramer Joel H, Rosen Howard, Miller Bruce L, Coppola Giovanni, Boxer Adam L

Abstract excerpt

OBJECTIVE: To identify genetic loci associated with plasma tau concentrations in healthy elders and individuals with Alzheimer disease. METHODS: Four hundred sixty-three non-Hispanic white individuals exceeding quality control criteria were included from the Alzheimer's Disease Neuroimaging Initiative (ADNI-1) cohort. Association of plasma tau with genetic polymorphisms was performed with a linear regression...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoprotein E4
Share to Cognitive Dysfunction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endophenotypes

Share to Genetic Loci

Share to Interleukin-2 Receptor alpha Subunit

Share to tau Proteins

Share to Ubiquitin-Protein Ligases

Share to United States

Source

Open in PubMed Open full text

Identifiers

PMID: 28100725
DOI: 10.1212/WNL.0000000000003615
PMCID: PMC5317386

Genes

MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide association study identifies MAPT locus influencing human plasma tau levels.PMID 28100725Read ↗

Meta-analysis of the association between variants in MAPT and neurodegenerative diseases.Semantic proximity Read ↗

Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus.Semantic proximity Read ↗

MAPT Haplotype Variation and Alzheimer's Disease Risk: A Narrative Review with Focus on the Jordanian Population.Semantic proximity Read ↗

Association of MAPT haplotypes with Alzheimer’s disease risk and MAPT brain gene expression levelsSemantic proximity Read ↗

The role of MAPT sequence variation in mechanisms of disease susceptibility.Semantic proximity Read ↗

Fine mapping of the MAPT locus using quantitative trait analysis identifies possible causal variants in Alzheimer's disease.Semantic proximity Read ↗

Variation in MAPT is associated with cerebrospinal fluid tau levels in the presence of amyloid-beta deposition.Semantic proximity Read ↗

The MAPT H1 haplotype is associated with tangle-predominant dementia.Semantic proximity Read ↗

Haplotypes and gene expression implicate the MAPT region for Parkinson disease: the GenePD Study.Semantic proximity Read ↗

Microtubule-associated protein tau (MAPT) influences the risk of Parkinson's disease among Indians.Semantic proximity Read ↗

Genetic Architecture of MAPT Gene Region in Parkinson Disease SubtypesSemantic proximity Read ↗

DNA Methylation in Genetic and Sporadic Forms of Neurodegeneration: Lessons From Alzheimers, Related Tauopathies and Genetic TauopathiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.