Lithium and GSK3-β promoter gene variants influence white matter microstructure in bipolar disorder.

doi:10.1038/npp.2012.172

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Article

Lithium and GSK3-β promoter gene variants influence white matter microstructure in bipolar disorder.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jan 2013

Benedetti Francesco, Bollettini Irene, Barberi Ignazio, Radaelli Daniele, Poletti Sara, Locatelli Clara, Pirovano Adele, Lorenzi Cristina, Falini Andrea, Colombo Cristina, Smeraldi Enrico

Abstract excerpt

Lithium is the mainstay for the treatment of bipolar disorder (BD) and inhibits glycogen synthase kinase 3-β (GSK3-β). The less active GSK3-β promoter gene variants have been associated with less detrimental clinical features of BD. GSK3-β gene variants and lithium can influence brain gray matter structure in psychiatric conditions. Diffusion tensor imaging (DTI) measures of white matter (WM) integrity showed...

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PMID: 22990942
DOI: 10.1038/npp.2012.172
PMCID: PMC3527112

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