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Article

Lithium and GSK-3β promoter gene variants influence cortical gray matter volumes in bipolar disorder.

Psychopharmacology - 1 Apr 2015

Benedetti Francesco, Poletti Sara, Radaelli Daniele, Locatelli Clara, Pirovano Adele, Lorenzi Cristina, Vai Benedetta, Bollettini Irene, Falini Andrea, Smeraldi Enrico, Colombo Cristina

Abstract excerpt

RATIONALE: Lithium is the mainstay for the treatment of bipolar disorder (BD) and inhibits glycogen synthase kinase-3β (GSK-3β). The less active GSK-3β promoter gene variants have been associated with less detrimental clinical features of BD. GSK-3β gene variants and lithium can influence brain gray and white matter structure in psychiatric conditions, so we studied their combined effect in BD. OBJECTIVES: The...

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Identifiers

PMID: 25345732
DOI: 10.1007/s00213-014-3770-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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