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Article

H1 haplotype of the MAPT gene is associated with lower regional gray matter volume in healthy carriers.

European journal of human genetics : EJHG - 1 Mar 2009

Canu Elisa, Boccardi Marina, Ghidoni Roberta, Benussi Luisa, Testa Cristina, Pievani Michela, Bonetti Matteo, Binetti Giuliano, Frisoni Giovanni B

Abstract excerpt

The microtubule-associated protein Tau (MAPT) gene codes for the protein Tau that is involved in the pathogenesis of neurodegenerative diseases. Recent studies have detected an over-representation of the H1 haplotype of the MAPT gene in neurodegenerative disorders such as progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), frontotemporal dementia (FTD) and Parkinson's disease (PD), whereas the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 18854867
DOI: 10.1038/ejhg.2008.185
PMCID: PMC2986165

Genes

MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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H1 haplotype of the MAPT gene is associated with lower regional gray matter volume in healthy carriers.PMID 18854867Read ↗

Brain hypometabolism in non-demented microtubule-associated protein tau H1 carriers with Parkinson's disease.Semantic proximity Read ↗

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Genetic Architecture of MAPT Gene Region in Parkinson Disease SubtypesSemantic proximity Read ↗

MAPT H1 haplotype is associated with enhanced α-synuclein deposition in dementia with Lewy bodies.Semantic proximity Read ↗

The MAPT H1 haplotype is associated with tangle-predominant dementia.Semantic proximity Read ↗

Selective brain gray matter atrophy associated with APOE ε4 and MAPT H1 in subjects with mild cognitive impairment.Semantic proximity Read ↗

From 1997 to 2007: a decade journey through the H1 haplotype on 17q21 chromosome.Semantic proximity Read ↗

The MAPT H1 Haplotype Is a Risk Factor for Alzheimer’s Disease in APOE ε4 Non-carriersSemantic proximity Read ↗

Brain volumetric deficits in MAPT mutation carriers: a multisite study.Semantic proximity Read ↗

Association analysis of MAPT H1 haplotype and subhaplotypes in Parkinson's disease.Semantic proximity Read ↗

Meta-analysis of the association between variants in MAPT and neurodegenerative diseases.Semantic proximity Read ↗

An evaluation of the impact of MAPT, SNCA and APOE on the burden of Alzheimer's and Lewy body pathology.Semantic proximity Read ↗

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