Article
Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus.
Molecular psychiatry - 1 Dec 2015
Desikan R S, Schork A J, Wang Y, Witoelar A, Sharma M, McEvoy L K, Holland D, Brewer J B, Chen C-H, Thompson W K, Harold D, Williams J, Owen M J, O'Donovan M C, Pericak-Vance M A, Mayeux R, Haines J L, Farrer L A, Schellenberg G D, Heutink P, Singleton A B, Brice A, Wood N W, Hardy J, Martinez M, Choi S H, DeStefano A, Ikram M A, Bis J C, Smith A, Fitzpatrick A L, Launer L, van Duijn C, Seshadri S, Ulstein I D, Aarsland D, Fladby T, Djurovic S, Hyman B T, Snaedal J, Stefansson H, Stefansson K, Gasser T, Andreassen O A, Dale A M
Abstract excerpt
We investigated the genetic overlap between Alzheimer's disease (AD) and Parkinson's disease (PD). Using summary statistics (P-values) from large recent genome-wide association studies (GWAS) (total n=89 904 individuals), we sought to identify single nucleotide polymorphisms (SNPs) associating with both AD and PD. We found and replicated association of both AD and PD with the A allele of rs393152 within the...
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