Article
MAPT rs242562 and GSK3B rs334558 are associated with Parkinson's Disease in central China.
BMC neuroscience - 29 Apr 2014
Yu Lan, Huang Jinsha, Zhai Desheng, Liu Ling, Guo Kexin, Long Xi, Xiong Jing, Zhang Zhentao, Wang Youpei, Zhao Ying, Wu Ping, Wang Dingan, Lin Zhicheng, Wu Jing, Xiong Nian, Wang Tao
Abstract excerpt
BACKGROUND: Microtubule-associated protein tau (MAPT) is a neuronal protein involved in the pathogenesis of several neurodegenerative diseases including Parkinson's Disease (PD). Glycogen synthase kinase 3 beta (GSK3B) catalyzes phosphorylation in multiple sites of tau protein. However, whether or not there is any association between the GSK3B gene alteration, MAPT haplotype and PD remains unexplored in Chinese...
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