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Article

Genetic variants of GSK3B are associated with biomarkers for Alzheimer's disease and cognitive function.

Journal of Alzheimer's disease : JAD - 1 Jan 2015

Kettunen Petronella, Larsson Susanna, Holmgren Sandra, Olsson Sandra, Minthon Lennart, Zetterberg Henrik, Blennow Kaj, Nilsson Staffan, Sjölander Annica

Abstract excerpt

BACKGROUND: Glycogen synthase kinase 3 beta (GSK3B) is the major kinase phosphorylating tau protein. Hyperphosphorylated tau is one of the hallmarks of Alzheimer's disease (AD). Despite extensive research, the role of GSK3B in AD pathogenesis is not fully understood. OBJECTIVE: To evaluate possible associations between gene variants of GSK3B and risk of AD. METHODS: Twelve GSK3B tag single-nucleotide...

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Identifiers

PMID: 25420549
DOI: 10.3233/JAD-142025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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