Article
Association of GSK-3β genetic variation with GSK-3β expression, prefrontal cortical thickness, prefrontal physiology, and schizophrenia.
The American journal of psychiatry - 1 Aug 2013
Blasi Giuseppe, Napolitano Francesco, Ursini Gianluca, Di Giorgio Annabella, Caforio Grazia, Taurisano Paolo, Fazio Leonardo, Gelao Barbara, Attrotto Maria Teresa, Colagiorgio Lucia, Todarello Giovanna, Piva Francesco, Papazacharias Apostolos, Masellis Rita, Mancini Marina, Porcelli Annamaria, Romano Raffaella, Rampino Antonio, Quarto Tiziana, Giulietti Matteo, Lipska Barbara K, Kleinman Joel E, Popolizio Teresa, Weinberger Daniel R, Usiello Alessandro, Bertolino Alessandro
Abstract excerpt
OBJECTIVE Glycogen synthase kinase 3β (GSK-3β) is an enzyme implicated in neurodevelopmental processes with a broad range of substrates mediating several canonical signaling pathways in the brain. The authors investigated the association of variation in the GSK-3β gene with a series of progressively more complex phenotypes of relevance to schizophrenia, a neurodevelopmental disorder with strong genetic risk....
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