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Article

Impact of genetic variants on hippocampal volume among individuals with schizophrenia and bipolar disorders.

Psychiatry research. Neuroimaging - 1 Apr 2026

Toffanin Tommaso, Perini Giulia Ida, Follador Halima, Zonta Filippo, Ferri Giovanni, Pigato Giorgio, Pagano Mario Angelo, Scupola Nadia, Pinato Claudia, Calosci Davide, Ferrara Maria, Muscettola Angela, De Bellis Giovanni Antonio, Montemitro Chiara, Zerbinati Luigi, Nanni Maria Giulia, Caruso Rosangela, Escelsior Andrea, Baratto Alessandra, Martino Nicola, Trevisson Eva, Olivo Daniele, Sambataro Fabio, Grassi Luigi, Murri Martino Belvederi

Abstract excerpt

BACKGROUND AND HYPOTHESIS: Hippocampal volume reduction is a consistent finding in schizophrenia (SCZ) and bipolar disorder type I (BP-I), yet the role of genetic factors remains unclear. We investigated the influence of DISC1 (rs821616), AKT1 (rs1130233), COMT (rs4680), and GSK-3ꞵ(rs334558) polymorphisms on hippocampal morphology. STUDY DESIGN: Seventy-one participants (25 SCZ, 22 BP-I, 24 healthy controls, HC)...

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Source

Identifiers

PMID: 41570363
DOI: 10.1016/j.pscychresns.2026.112147

Genes

COMT
DISC1
AKT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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