Article
Genetic variation in the base excision repair pathway, environmental risk factors, and colorectal adenoma risk.
PloS one - 1 Jan 2013
Corral Roman, Lewinger Juan Pablo, Joshi Amit D, Levine A Joan, Vandenberg David J, Haile Robert W, Stern Mariana C
Abstract excerpt
Cigarette smoking, high alcohol intake, and low dietary folate levels are risk factors for colorectal adenomas. Oxidative damage caused by these three factors can be repaired through the base excision repair pathway (BER). We hypothesized that genetic variation in BER might modify colorectal adenoma risk. In a sigmoidoscopy-based study, we examined associations between 182 haplotype tagging SNPs in 14 BER genes,...
Topics
- Adenoma
- Adult
- Aged
- Colorectal Neoplasms
- DNA Repair
- Environment
- Female
- Gene-Environment Interaction
- Genetic Variation
- Humans
- Male
- Middle Aged
- Neoplasm Staging
- Polymorphism, Single Nucleotide