Article
DNA repair gene polymorphisms and tobacco smoking in the risk for colorectal adenomas.
Carcinogenesis - 1 Jun 2011
Gao Ying, Hayes Richard B, Huang Wen-Yi, Caporaso Neil E, Burdette Laurie, Yeager Meredith, Chanock Stephen J, Berndt Sonja I
Abstract excerpt
DNA damage is thought to play a critical role in the development of colorectal adenoma. Variation in DNA repair genes may alter their capacity to correct endogenous and exogenous DNA damage. We explored the association between common single-nucleotide polymorphisms (SNPs) in DNA repair genes and adenoma risk with a case-control study nested in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. A...
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