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Article

Genetic variation in base excision repair genes and the prevalence of advanced colorectal adenoma.

Cancer research - 1 Feb 2007

Berndt Sonja I, Huang Wen-Yi, Fallin M Daniele, Helzlsouer Kathy J, Platz Elizabeth A, Weissfeld Joel L, Church Timothy R, Welch Robert, Chanock Stephen J, Hayes Richard B

Abstract excerpt

Base excision repair (BER) corrects DNA damage caused by oxidative stress and low folate intake, which are putative risk factors for colorectal neoplasia. To examine the relationship between genetic variation in BER genes and colorectal adenoma risk, we conducted a case-control study of 767 cases of advanced colorectal adenoma and 773 controls from the baseline screening exam of the Prostate, Lung, Colorectal,...

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Source

Identifiers

PMID: 17283177
DOI: 10.1158/0008-5472.CAN-06-1390

Genes

PARP1
APEX1
XRCC1
POLB

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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