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Article

Reversal of neurofibrillary tangles and tau-associated phenotype in the rTgTauEC model of early Alzheimer's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 14 Aug 2013

Polydoro Manuela, de Calignon Alix, Suárez-Calvet Marc, Sanchez Laura, Kay Kevin R, Nicholls Samantha B, Roe Allyson D, Pitstick Rose, Carlson George A, Gómez-Isla Teresa, Spires-Jones Tara L, Hyman Bradley T

Abstract excerpt

Neurofibrillary tangles (NFTs), a marker of neuronal alterations in Alzheimer's disease (AD) and other tauopathies, are comprised of aggregates of hyperphosphorylated tau protein. We recently studied the formation of NFTs in the entorhinal cortex (EC) and their subsequent propagation through neur...

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Identifiers

PMID: 23946388
DOI: 10.1523/JNEUROSCI.0881-13.2013
PMCID: PMC3742920

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23946388-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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