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Article

Expression of P301L-hTau in mouse MEC induces hippocampus-dependent memory deficit.

Scientific reports - 20 Jun 2017

Liu Xinghua, Zeng Kuan, Li Mengzhu, Wang Qun, Liu Rong, Zhang Bin, Wang Jian-Zhi, Shu Xiji, Wang Xiaochuan

Abstract excerpt

Intracellular accumulation of abnormally phosphorylated tau in different types of neurons is a pathological characteristic of Alzheimer's disease (AD). While tau modification and associated neuronal loss and hypometabolism start in the entorhinal cortex (EC) in early AD patients, the mechanism by which mutant P301L hTau leads to dementia is not fully elucidated. Here, we studied the effects of P301L hTau...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28634382
DOI: 10.1038/s41598-017-04305-4
PMCID: PMC5478664

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