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Article

Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early A lzheimer's disease

14 Feb 2017

Abstract excerpt

Synaptic dysfunction and loss is the strongest pathological correlate of cognitive decline in Alzheimer's disease (AD) with increasing evidence implicating neuropathological tau protein in this process. Despite the knowledge that tau spreads through defined synaptic circuits, it is currently unknown whether synapse loss occurs before the accumulation of tau or as a consequence. To address this, we have used array...

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PMID: 28196395
DOI: 10.1002/syn.21965

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