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Tau-Driven Neuronal and Neurotrophic Dysfunction in a Mouse Model of Early Tauopathy

17 Feb 2016

Abstract excerpt

Tauopathies are neurodegenerative diseases characterized by intraneuronal inclusions of hyperphosphorylated tau protein and abnormal expression of brain-derived neurotrophic factor (BDNF), a key modulator of neuronal survival and function. The severity of both these pathological hallmarks correlate with the degree of cognitive impairment in patients. However, how tau pathology specifically modifies BDNF signaling...

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PMID: 26888921
DOI: 10.1523/jneurosci.0774-15.2016

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