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Article

Early structural and functional defects in synapses and myelinated axons in stratum lacunosum moleculare in two preclinical models for tauopathy.

PloS one - 1 Jan 2014

Maurin Hervé, Chong Seon-Ah, Kraev Igor, Davies Heather, Kremer Anna, Seymour Claire Marie, Lechat Benoit, Jaworski Tomasz, Borghgraef Peter, Devijver Herman, Callewaert Geert, Stewart Michael G, Van Leuven Fred

Abstract excerpt

The stratum lacunosum moleculare (SLM) is the connection hub between entorhinal cortex and hippocampus, two brain regions that are most vulnerable in Alzheimer's disease. We recently identified a specific synaptic deficit of Nectin-3 in transgenic models for tauopathy. Here we defined cognitive i...

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Identifiers

PMID: 24498342
DOI: 10.1371/journal.pone.0087605
PMCID: PMC3912020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24498342-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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