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The Olfactory Epithelium: A Critical Gateway for Pathological Tau Propagation and a Target for Mitigating Tauopathy in the Central Nervous System

2025-03-10

Abstract excerpt

Olfactory impairment is a recognized early indicator of neurodegenerative diseases (NDs), such as Alzheimer’s disease (AD). Intracellular aggregates of hyperphosphorylated tau protein, referred to as neurofibrillary tangles (NFTs), are a hallmark of AD. NFTs are found in the olfactory bulb (OB) and entorhinal cortex (EC), both crucial for processing olfactory information. We explored the hypothesis that typical ta...

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Literature Corpus work
585832e4-0b9f-584c-b1cc-410ae59ac452
DOI
10.1101/2025.03.03.637437
Open publication

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The Olfactory Epithelium: A Critical Gateway for Pathological Tau Propagation and a Target for Mitigating Tauopathy in the Central Nervous SystemDOI 10.1101/2025.03.03.637437
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