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Article

Transsynaptic progression of amyloid-β-induced neuronal dysfunction within the entorhinal-hippocampal network.

Neuron - 4 Nov 2010

Harris Julie A, Devidze Nino, Verret Laure, Ho Kaitlyn, Halabisky Brian, Thwin Myo T, Kim Daniel, Hamto Patricia, Lo Iris, Yu Gui-Qiu, Palop Jorge J, Masliah Eliezer, Mucke Lennart

Abstract excerpt

The entorhinal cortex (EC) is one of the earliest affected, most vulnerable brain regions in Alzheimer's disease (AD), which is associated with amyloid-β (Aβ) accumulation in many brain areas. Selective overexpression of mutant amyloid precursor protein (APP) predominantly in layer II/III neurons...

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Source

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Identifiers

PMID: 21040845
DOI: 10.1016/j.neuron.2010.10.020
PMCID: PMC3050043

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21040845-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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