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Article

Cholinergic Basal Forebrain Lesion Decreases Neurotrophin Signaling without Affecting Tau Hyperphosphorylation in Genetically Susceptible Mice.

Journal of Alzheimer's disease : JAD - 1 Jan 2017

Turnbull Marion T, Coulson Elizabeth J

Abstract excerpt

Alzheimer's disease (AD) is a progressive, irreversible neurodegenerative disease that destroys memory and cognitive function. Aggregates of hyperphosphorylated tau protein are a prominent feature in the brain of patients with AD, and are a major contributor to neuronal toxicity and disease progression. However, the factors that initiate the toxic cascade that results in tau hyperphosphorylation in sporadic AD...

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Identifiers

PMID: 27767994
DOI: 10.3233/JAD-160805

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