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Article

Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 10 May 2006

Engel Tobias, Hernández Félix, Avila Jesús, Lucas José J

Abstract excerpt

Glycogen synthase kinase-3 (GSK-3) is a ubiquitously expressed serine/threonine kinase that is particularly abundant in the CNS. Dysregulation of GSK-3 activity is believed to play a key role in the pathogenesis of CNS chronic disorders such as Alzheimer's disease (AD), bipolar disorder, and Huntington's disease, and of metabolic disorders such as type II diabetes. Accordingly, GSK-3 inhibitors have been...

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Identifiers

PMID: 16687499
DOI: 10.1523/JNEUROSCI.0604-06.2006
PMCID: PMC6674262

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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