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Article

Focal expression of mutated tau in entorhinal cortex neurons of rats impairs spatial working memory.

Behavioural brain research - 1 Jan 2011

Ramirez Julio J, Poulton Winona E, Knelson Erik, Barton Cole, King Michael A, Klein Ronald L

Abstract excerpt

Entorhinal cortex neuropathology begins very early in Alzheimer's disease (AD), a disorder characterized by severe memory disruption. Indeed, loss of entorhinal volume is predictive of AD and two of the hallmark neuroanatomical markers of AD, amyloid plaques and neurofibrillary tangles (NFTs), are particularly prevalent in the entorhinal area of AD-afflicted brains. Gene transfer techniques were used to create a...

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Identifiers

PMID: 20727915
DOI: 10.1016/j.bbr.2010.08.013
PMCID: PMC2975819

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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