Article
LRRK2: Genetic mechanisms vs genetic subtypes.
Handbook of clinical neurology - 1 Jan 2023
Mata Ignacio, Salles Philippe, Cornejo-Olivas Mario, Saffie Paula, Ross Owen A, Reed Xylena, Bandres-Ciga Sara
Abstract excerpt
In 2004, the identification of pathogenic variants in the LRRK2 gene across several families with autosomal dominant late-onset Parkinson's disease (PD) revolutionized our understanding of the role of genetics in PD. Previous beliefs that genetics in PD was limited to rare early-onset or familial forms of the disease were quickly dispelled. Currently, we recognize LRRK2 p.G2019S as the most common genetic cause...
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