LRRK2 in Parkinson's disease: genetic and clinical studies from patients.

Abstract excerpt

Mutations in leucine-rich repeat kinase 2 (LRRK2) (PARK8) are associated with both familial and sporadic forms of Parkinson's disease. Most studies have shown that LRRK2 mutations may explain between 5% and 13% of familial and 1-5% of sporadic Parkinson's disease. Importantly, a common recurrent mutation (G2019S) located in the kinase domain has been reported across most ethnic populations, with the highest...

Topics

• Genetic Testing
• Genotype
• Humans
• Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
• Mutation
• Parkinson Disease
• Phenotype
• Polymorphism, Genetic
• Protein Serine-Threonine Kinases