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Article

Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease.

Annals of neurology - 1 Jul 2008

Ross Owen A, Wu Yih-Ru, Lee Mei-Ching, Funayama Manabu, Chen Meng-Ling, Soto Alexandra I, Mata Ignacio F, Lee-Chen Guey-Jen, Chen Chiung Mei, Tang Michelle, Zhao Yi, Hattori Nobutaka, Farrer Matthew J, Tan Eng-King, Wu Ruey-Meei

Abstract excerpt

Common genetic variants that increase the risk for Parkinson's disease may differentiate patient subgroups and influence future individualized therapeutic strategies. Herein we show evidence for leucine-rich repeat kinase 2 (LRRK2) c.4883G>C (R1628P) as a risk factor in ethnic Chinese populations. A study of 1,986 individuals from 3 independent centers in Taiwan and Singapore demonstrates that Lrrk2 R1628P...

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PMID: 18412265
DOI: 10.1002/ana.21405

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease.PMID 18412265Read ↗

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LRRK2 R1628P variant is a risk factor of Parkinson's disease among Han-Chinese from mainland China.Semantic proximity Read ↗

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LRRK2 G2385R and LRRK2 R1628P increase risk of Parkinson's disease in a Han Chinese population from Southern Mainland ChinaSemantic proximity Read ↗

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