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Article

APOE interacts with age to modify rate of decline in cognitive and brain changes in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 May 2014

Chang Yu-Ling, Fennema-Notestine Christine, Holland Dominic, McEvoy Linda K, Stricker Nikki H, Salmon David P, Dale Anders M, Bondi Mark W

Abstract excerpt

OBJECTIVE: To determine (1) whether age-standardized cognitive declines and brain morphometric change differ between Young-Old patients with Alzheimer's disease (YOAD) and Very-Old patients with Alzheimer's disease (VOAD), and (2) whether the apolipoprotein E (APOE) genotype modifies these neuropsychological and morphometric changes. METHODS: Baseline and 12-month follow-up neuropsychological and morphometric...

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Source

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Identifiers

PMID: 23896613
DOI: 10.1016/j.jalz.2013.05.1763
PMCID: PMC3815680

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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