Article
Age and apolipoprotein E genotype influence rate of cognitive decline in nondemented elderly.
Neuropsychology - 1 Jul 2013
Salmon David P, Ferris Steven H, Thomas Ronald G, Sano Mary, Cummings Jeffery L, Sperling Reisa A, Petersen Ronald C, Aisen Paul S
Abstract excerpt
OBJECTIVE: This study examined the impact of age and apolipoprotein E (APOE) genotype on the rate of cognitive decline in nondemented elderly participants in a simulated Alzheimer's disease (AD) primary prevention treatment trial carried out by the Alzheimer's Disease Cooperative Study. METHOD: Cognitive tests were administered at baseline and at four subsequent annual evaluations to 417 nondemented participants...
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