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Article

Longitudinal brain imaging in preclinical Alzheimer disease: impact of APOE ε4 genotype.

Brain : a journal of neurology - 1 Jun 2018

Mishra Shruti, Blazey Tyler M, Holtzman David M, Cruchaga Carlos, Su Yi, Morris John C, Benzinger Tammie L S, Gordon Brian A

Abstract excerpt

While prior work reliably demonstrates that the APOE ɛ4 allele has deleterious group level effects on Alzheimer disease pathology, the homogeneity of its influence across the lifespan and spatially in the brain remains unknown. Further it is unclear what combinations of factors at an individual level lead to observed group level effects of APOE genotype. To evaluate the impact of the APOE genotype on disease...

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Source

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Identifiers

PMID: 29672664
DOI: 10.1093/brain/awy103
PMCID: PMC5972633

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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