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Article

The autoimmune disease-associated SNP rs917997 of IL18RAP controls IFNγ production by PBMC.

Journal of autoimmunity - 1 Aug 2013

Myhr Courtney B, Hulme Maigan A, Wasserfall Clive H, Hong Peter J, Lakshmi Priya Saikumar, Schatz Desmond A, Haller Michael J, Brusko Todd M, Atkinson Mark A

Abstract excerpt

Type 1 Diabetes (T1D) is an autoimmune disorder characterized by aberrant T cell responses. Innate immune activation defects may facilitate a T helper 1 (Th1) phenotype. The cytokine IL-18 synergizes with IL-12 to induce IFNγ production and Th1 differentiation. The IL-18R subunit (IL18RAP) SNP rs917997 has been linked to decreased IL18RAP gene expression. Prior reports link rs917997 allele A with protection from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Autoimmune Diseases
Share to Diabetes Mellitus, Type 1
Share to Interferon-gamma
Share to Interleukin-12
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Source

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Identifiers

PMID: 23891168
DOI: 10.1016/j.jaut.2013.06.001
PMCID: PMC3775347

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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