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Article

Innate inflammation drives NK cell activation to impair Treg activity.

Journal of autoimmunity - 1 Mar 2020

Dean Joseph W, Peters Leeana D, Fuhrman Christopher A, Seay Howard R, Posgai Amanda L, Stimpson Scott E, Brusko Maigan A, Perry Daniel J, Yeh Wen-I, Newby Brittney N, Haller Michael J, Muir Andrew B, Atkinson Mark A, Mathews Clayton E, Brusko Todd M

Abstract excerpt

IL-12 and IL-18 synergize to promote TH1 responses and have been implicated as accelerators of autoimmune pathogenesis in type 1 diabetes (T1D). We investigated the influence of these cytokines on immune cells involved in human T1D progression: natural killer (NK) cells, regulatory T cells (Tregs), and cytotoxic T lymphocytes (CTL). NK cells from T1D patients exhibited higher surface CD226 versus controls and...

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Share to Cytotoxicity, Immunologic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Killer Cells, Natural

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Share to T-Lymphocytes, Cytotoxic

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Identifiers

PMID: 32035746
DOI: 10.1016/j.jaut.2020.102417
PMCID: PMC7086400

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