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Article

Genes of the interleukin-18 pathway are associated with susceptibility to Barrett's esophagus and esophageal adenocarcinoma.

The American journal of gastroenterology - 1 Sept 2012

Babar Mahwash, Ryan Anthony W, Anderson Lesley A, Segurado Ricardo, Turner Graham, Murray Liam J, Murphy Seamus J, Johnston Brian T, Comber Harry, Reynolds John V, McManus Ross

Abstract excerpt

OBJECTIVES: To investigate the association of genetic polymorphisms of the interleukin-18 (IL-18) pathway to Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC). Most cases of EAC arise in a background of reflux-induced BE. Genetic influences in this pathway are poorly understood. IL-18 is a multifunctional cytokine implicated in anti-tumor immunity. A number of polymorphisms of the IL-18 and IL-18...

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Identifiers

PMID: 22664470
DOI: 10.1038/ajg.2012.134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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