Article
Identification of IL18RAP/IL18R1 and IL12B as leprosy risk genes demonstrates shared pathogenesis between inflammation and infectious diseases.
American journal of human genetics - 2 Nov 2012
Liu Hong, Irwanto Astrid, Tian Hongqing, Fu Xi'an, Yu Yongxiang, Yu Gongqi, Low Huiqi, Chu Tongsheng, Li Yi, Shi Benqing, Chen Mingfei, Sun Yonghu, Yuan Chunying, Lu Nan, You Jiabao, Bao Fangfang, Li Jinghui, Liu Jian, Liu Huaxu, Liu Dianchang, Yu Xiulu, Zhang Lin, Yang Qing, Wang Na, Niu Guiye, Ma Shanshan, Zhou Yan, Wang Chuan, Chen Shumin, Zhang Xuejun, Liu Jianjun, Zhang Furen
Abstract excerpt
Of eight leprosy susceptibility loci identified by genome-wide association studies, five have been implicated in Crohn disease, suggesting a common genetic fingerprint between leprosy and inflammatory bowel disease (IBD). Here, we conducted a multiple-stage genetic association study of 133 IBD susceptibility loci in multiple leprosy samples (totaling 4,971 leprosy cases and 5,503 controls) from a Chinese...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.