Article
The IL23R R381Q gene variant protects against immune-mediated diseases by impairing IL-23-induced Th17 effector response in humans.
PloS one - 22 Feb 2011
Di Meglio Paola, Di Cesare Antonella, Laggner Ute, Chu Chung-Ching, Napolitano Luca, Villanova Federica, Tosi Isabella, Capon Francesca, Trembath Richard C, Peris Ketty, Nestle Frank O
Abstract excerpt
IL-23 and Th17 cells are key players in tissue immunosurveillance and are implicated in human immune-mediated diseases. Genome-wide association studies have shown that the IL23R R381Q gene variant protects against psoriasis, Crohn's disease and ankylosing spondylitis. We investigated the immunological consequences of the protective IL23R R381Q gene variant in healthy donors. The IL23R R381Q gene variant had no...
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