Article
Gene expression changes with age in skin, adipose tissue, blood and brain.
Genome biology - 26 Jul 2013
Glass Daniel, Viñuela Ana, Davies Matthew N, Ramasamy Adaikalavan, Parts Leopold, Knowles David, Brown Andrew A, Hedman Asa K, Small Kerrin S, Buil Alfonso, Grundberg Elin, Nica Alexandra C, Di Meglio Paola, Nestle Frank O, Ryten Mina, Durbin Richard, McCarthy Mark I, Deloukas Panagiotis, Dermitzakis Emmanouil T, Weale Michael E, Bataille Veronique, Spector Tim D
Abstract excerpt
BACKGROUND: Previous studies have demonstrated that gene expression levels change with age. These changes are hypothesized to influence the aging rate of an individual. We analyzed gene expression changes with age in abdominal skin, subcutaneous adipose tissue and lymphoblastoid cell lines in 856 female twins in the age range of 39-85 years. Additionally, we investigated genotypic variants involved in...
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