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Article

Aging is associated with highly defined epigenetic changes in the human epidermis

31 Oct 2013

Abstract excerpt

BACKGROUND: Altered DNA methylation patterns represent an attractive mechanism for understanding the phenotypic changes associated with human aging. Several studies have described global and complex age-related methylation changes, but their structural and functional significance has remained largely unclear. RESULTS: We have used transcriptome sequencing to characterize age-related gene expression changes in the...

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PMID: 24279375
DOI: 10.1186/1756-8935-6-36

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